Hyaluronic Acid – Properties, Benefits and Side Effects


The hyaluronic acid is a molecule with many properties for the simple reason that it is very abundant in our body. The external contribution gives it multiple uses, from the filling of wrinkles with creams to the “regeneration” of cartilage tissue by viscosupplementation. Below you have the index of this article. Click on the section that interests you the most.

Hyaluronic acid is a molecule belonging to the glycosaminoglycan (GAG) family. It is naturally present in all cells of the human body, but especially in the outermost layers of the skin and in the joints. Hence, it has innumerable properties in the field of beauty and aesthetics, in addition to regenerative medicine to treat diseases such as osteoarthritis or arthritis.

Also known as sodium hyaluronate or sodium hyaluronate, in this article you will learn all the details about its benefits, what it is for, how it is applied in the world of beauty and health, and some side effects and contraindications of viscosupplementation.

What is hyaluronic acid for and what are its properties?

Many are the properties that have been attributed to this long polysaccharide since it was discovered by Karl Meyer in the 1930s. Here we discover some.

  • Hydrate. One of its main functions is to retain water, which provides deep hydration to the skin. In this way, the cells manage to maintain their turgor and elasticity.
  • Anti-aging. Many creams contain hyaluronate for its regenerative action. Cell renewal is an essential event to prevent aging, and hyaluronic acid participates in two vital processes of a cell: division and proliferation.
  • It contributes to the elimination of free radicals, improving the condition of the skin and protecting it against the ultraviolet rays of the sun. Some sunscreens incorporate a small percentage of cross-linked hyaluronic acid to keep skin healthy for long periods in the sun. This also helps to keep the genetic material (DNA and RNA) protected from mutations caused by these radiations.
  • It takes part in the repair of the tissues. A benefit that serves both aesthetics and medicine. Hyaluronic acid is highly present in the dermis and joints, so it is infiltrated as a filler for wrinkles and to stimulate joint regeneration in patients with osteoarthritis.
  • It is a great shock absorber. The sodium hyaluronate present in the synovial fluid reduces friction between the bones, considerably improving mobility problems.
  • It has a structural role in cartilage.
  • It stimulates collagen production.
  • Strengthens tendons and ligaments.

Hyaluronic acid applications in medicine and aesthetics

Hyaluronic acid has different applications in various sectors of health and beauty. Let’s look at them one by one, starting with topical use.

On the face and hair

The face is one of the parts of the body most affected by inclement weather, since we wear it uncovered every day. Its application for dark circles is also useful.

The natural hyaluronic acid present in creams and other cosmetics contributes to the structural role of cells, providing turgor and elasticity. In fact, a hyaluronic acid cosmetic has been shown to provide greater elasticity to the dermis than one based on collagen.

In addition, as it helps in cell regeneration and hydrates maintaining the necessary water levels, it fights the different signs of aging. It can be applied to the face with creams or capsules of concentrated hyaluronic acid. Apparently it is more effective than collagen.

On the lips, nose, or buttocks

In the lips, pure hyaluronic acid is used as a filler implant. The purpose is to increase the volume through an infiltration of active principle. Its action is long-lasting and has a more positive effect than botulinum toxin. Additionally, there are those who inject it into the nose and buttocks.

In regenerative medicine

  • In osteoarthritic patients and in rehabilitation, especially in cases that affect the knee, hyaluronic acid is infiltrated through a specific process called viscosupplementation. This is because the joints are made up of a high concentration of the polysaccharide. Viscosupplementation helps to lubricate the osteoarthritic area and serves as a lubricating remedy. Although it is not completely proven, some scientific researchers think that it could delay the progression of osteoarthritis. What is certain is that viscosupplementation has a long-lasting action that can take effect for a whole year, reducing rigidity.
  • In ophthalmology, the possibility has been seen that it improves the condition of cataracts when injected during an operation.
  • For mouth ulcers, some doctors recommend sodium hyaluronate gels to relieve pain. There is no complete certainty in this regard.
  • Strengthens the connective tissue, acting directly on tendons and ligaments.

In scientific research

In the field of research, it is a molecular marker used to diagnose different diseases, since it reacts with different molecules and serves to detect signaling pathways involved in various pathologies.

Side effects and contraindications of hyaluronic acid

At the moment no side effects have been detected with hyaluronic within the indicated doses and forms, unless the patient is hypersensitive to any of the cosmetic / drug compounds. This is what is known at the moment:

  • It is considered as a probably safe compound, when it is applied by injection, or with cosmetics on the skin.
  • During pregnancy, there is no conclusive study when taken by mouth. Therefore, if you are pregnant, I recommend that you wait until delivery to continue your treatment. Instead, it is probably safe if used on the skin or localized injections (knee, elbow, etc.).
  • While breastfeeding, hyaluronic acid is probably unsafe when given by injection. I recommend that you finish this phase before using it.

What is the best hyaluronic acid cosmetic on the market?

We recommend Snake Action Plus from Dermohelp. If what you are looking for is a cream to fill in wrinkles with a tightening effect, it is the best option. Contains hyaluronate and snake venom. It is very competitively priced for the quality of the product. Then there are the pills and capsules, which we do not recommend at all based on the opinions about adverse effects that we have found.


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